Hydrochloric Acid → 4-Azido-3-iodobenzoic acid

Participants

Reaction Conditions

Reaction Steps

To a solution of the azido-ester from Step 2 (1.0 eq) in 6 mL of THF (0.2M) was added LiOH (2 N in H2O; 1.5 eq). The resulting mixture was stirred at 50° C. for 4 h, then acidified to pH 4 using HCl (1N) and extracted with Et2O (3×). The combined organic extracts were washed with water, brine, dried over MgSO4, filtered and concentrated to afford the 4-azido-3-iodo-benzoic acid compound as a light yellow solid.

Provenance & Evidence