HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Chloroethyl)-4-(methylsulfonyl)piperazine → 6-(2-Chloroethyl)-2-oxa-6-azaspiro[3.3]heptane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Chloroethyl)-4-(methylsulfonyl)piperazine | HCID 20158350 | — |
| Reactant | 2-Oxa-6-azaspiro[3.3]heptane | HCID 23111887 | — |
| Product | 6-(2-Chloroethyl)-2-oxa-6-azaspiro[3.3]heptane | HCID 68275939 | — |
Reaction Steps
The title compound was prepared following the method described above for the synthesis of 1-(2-chloroethyl)-4-(methylsulfonyl)piperazine using 2-oxa-6-azaspiro[3.3]heptane as the starting reagent. The product was isolated as colorless oil (10 mg, 12%). LCMS: m/e 162.15 (M+H)+, 0.87 min (method 10).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846647B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-0099398f1d1a4ecea0b0514be075a909 |
| Source note | uspto-grants-2014_09 |