Dimethylformamide → HCID 10128861, compound

Participants

Reaction Steps

To solution of Quinoline 12 (1.0 eq) and 1-(2-hydroxy-5-methanesulfonyl-phenyl)-ethanone (1.08 eq) (from the procedure described in Synthesis, 1982, 11, 940) in DMF (0.05M) was added Cs2CO3 (1.08 eq). The mixture was stirred for 12 h then poured in saturated aqueous NH4Cl and extracted with EtOAc (2×). The combined organic extracts were washed with brine, dried over MgSO4, filtered and concentrated. Flash chromatography (CH2Cl2:EtOAc; 50 to 100%) afforded the title compound as a white solid.

Provenance & Evidence