HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 857306Generated: October 31, 2026
Sodium Carbonate → HCID 21865556, compound
https://huagongshe.com/reaction/857306
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-(Methylthio)phenylboronic acid | HCID 2733959 | — |
| Reactant | HCID 21865605 | HCID 21865605 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | HCID 21865556 | HCID 21865556 | — |
Reaction Steps
A mixture of N-(6-Chloro-pyridin-3-yl)-3-[6-(1-methanesulfonyl-1-methyl-ethyl)-quinolin-8-yl]-benzamide, 4-methylsulfanyl-phenyl boronic acid (2 eq), PdCl2(dppf)2 (0.05 eq) and aqueous Na2CO3 (4 eq) in DME (0.04M from benzamide) was stirred at 100° C. for 12 h. The resulting mixture was poured in water and extracted with EtOAc (2×). The combined organic extracts were washed with water, brine, dried over MgSO4, filtered and concentrated. Flash chromatography (EtOAc) afforded the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07144896B2 |
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| Source dataset | uspto-grants-2006_12 |
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| ORD ID | ord-7540f267a67647d187b76fafb7718204 |
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| Source note | uspto-grants-2006_12 |
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