Sodium hydride → HCID 21867524, compound

Participants

Reaction Steps

To a vigorously stirred solution of 0.32 g of the product from Step 2 of Example 1 in 5 mL of DMF was added sequentially 0.055 g NaH (60% in mineral oil), 0.27 mL of 2-(2-bromoethyl)-1,3-dioxolane and 0.01 g of n-Bu4NI. The mixture was stirred for 3 hours at room temperature and then quenched with 5 mL of saturated aqueous solution of NH4Cl and 5 mL of water, and extracted with 50 mL of 1:1 hexane/EtOAc. The extract was dried over Na2SO4 and concentrated. The residue was purified by silica gel flash chromatography eluted with 9:1 hexane/EtOAc to give 0.3 g of the title compound as an oil.

Provenance & Evidence