Ethyl 2-methylacetoacetate → HCID 21867437, compound

HRID 857315Notes

Reaction equation

HRID 857315 reaction equation
[CH3:1][S:2][C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][CH:9]=1)[NH2:6].[CH3:10][CH:11](C(C)=O)[C:12]([O:14][CH2:15][CH3:16])=[O:13].COC1C=C2C(C(C)=C(C(OCC)=O)N2)=CC=1>>[CH3:1][S:2][C:3]1[CH:4]=[C:5]2[C:7]([CH:10]=[C:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[NH:6]2)=[CH:8][CH:9]=1

Participants

4

Reactant 3

HCID 701Ethyl 2-methylacetoacetateHCID 15693Benzenamine, 3-(methylthio)-HCID 12438714Ethyl 6-methoxy-3-methyl-1H-indole-2-carboxylate

Product 1

HCID 21867437HCID 21867437, compound

Procedure

Starting from 3-(methylthio)aniline and ethyl 2-methylacetoacetate, th title compound was prepared by following the published procedure for ethyl 6-methoxy-3-methyl-1H-2-indolecarboxylate (T. Gan et al, J. Org. Chem. 1997, 62, 9298–9304).

Sources & evidence

ORD record
ord-a8961afa72114155a6f9eb875b8e2f6c
Source dataset
uspto-grants-2006_12
Patent number
US07144913B2

Reaction notes

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