HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → Ethyl 3-(4-chlorophenyl)-4-(methylsulfanyl)-1h-indole-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | (+/-)-[10-(4-Chlorophenyl)-1-(methylsulfinyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl]acetic acid | HCID 21867520 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | Ethyl 3-(4-chlorophenyl)-4-(methylsulfanyl)-1h-indole-2-carboxylate | HCID 21867418 | — |
Reaction Steps
To a solution of the indole of step 3 (2.1 g) in 200 mL of EtOAc was added 5% palladium on carbon (1 g). The mixture was shaken under H2 atmosphere (50 psi) for 24 hours, filtered on a silica gel pad eluted with EtOAc and the filtrate concentrated to give the title compound as a white solid (1.5 g) used as such.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07144913B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-cc1c75be34d14fffbf44e42c708dcd7a |
| Source note | uspto-grants-2006_12 |