Water → HCID 21867506, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the indole of Step 5 (1.9 g, 4.3 mmol) in THF (20 ml at 0° C. was added 1M TBAF (7 mL, 6 mmol). The reaction mixture was stirred for 1 minutes at 0° C. and water was added. The phases were separated and the aqueous layer was extracted with Et2O. The combined organic layers were dried over MgSO and concentrated The residue was purified by silica gel chromatography eluted with 20% EtOAc in Hexanes to provide 700 mg of the title compound as a pale yellow oil.

Provenance & Evidence