N-bromobutanimide → HCID 21867514, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the indole of Step 6 (700 mg, 2.4 mmol) in CCl4 (15 mL) was added NBS (475 mg, 2.7 mmol). The reaction mixture was heated to 50° C. and stirred for 20 minutes. The resulting suspension was filtered on SiO2 pad eluted with 50% EtOAc in hexanes and concentrated. The title compound was obtained in quantitative yield as a brownish solid foam and used as such.

Provenance & Evidence