Lithium Hydroxide → HCID 21867471, compound

Participants

Reaction Steps

To a solution of the ester of Step 13 (70 mg) in a THF/MeOH (3:1) mixture at r.t. was added 1N LiOH (aqueous solution). The reaction mixture was stirred at r.t. for 2 h and AcOH was added. The aqueous layer was extracted with EtOAc and the combined organic layers were dried over Na2SO4 and concentrated. The residue was swished in EtOAc/MeOH to give 35 mg of the desired acid as a white solid.

Provenance & Evidence