Acetic Acid → HCID 10226143, compound

Participants

Reaction Steps

To a solution of the ester of Step 9 (80 mg) in a 3:1 mixture of THF/MeOH (3 mL) at r.t. was added 1N LiOH (1 mL, aqueous solution). The reaction mixture was stirred at r.t. for 2 h and AcOH (0.5 mL) and brine (5 mL) were added. The aqueous layer was extracted with EtOAc and the combined organic layers were dried over Na2SO4 and concentrated. The residue was purified by silica gel chromatography eluted with 40% EtOAc/hexane containing 1% AcOH to provide 70 mg of the title compound as a pale yellow solid.

Provenance & Evidence