Hydrochloric Acid → HCID 58760777, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the indole of Step 2 (460 mg, 0.9 mmol) in THF (100 mL) at 0° C. was added potassium t-butoxide (1.2 mL of a 1M solution in THF The reaction mixture was stirred for 2 hours at 0° C. and 1N HCl was added. The phases were separated and the aqueous layer was extracted with EtOAc. The combined organic layers were dried over Na2SO4 and concentrated to give 400 mg of a pale yellow solid used as such.

Provenance & Evidence