Hydrochloric Acid → HCID 10205646, compound

Participants

Reaction Steps

To a solution of (+/−)-[9-[(4-chlorophenyl)sulfanyl]-6-fluoro-8-(trifluoroacetyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetic acid (Example 11, 78 mg) in MeOH (5 mL) at r.t. was added 50 mg of NaBH4. The reaction mixture was stirred at r.t. for 3 hours and 1N HCl was slowly added The aqueous layer was extracted with EtOAc and the combined organic layers were dried over Na2SO4 and concentrated. The residue was purified by silica gel chromatography eluted with EtOAc/Hexanes/AcOH (20:30:1) to provide 60 mg of the title compound as a white solid.

Provenance & Evidence