Diethyl Ether → HCID 91424771, compound

HRID 857352Notes

Reaction equation

HRID 857352 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[C:17]3[C:16]([CH:18]([OH:20])[CH3:19])=[CH:15][C:14]([F:21])=[CH:13][C:12]=3[N:11]3[CH2:22][CH2:23][CH:24]([CH2:25][C:26]([OH:28])=[O:27])[C:10]=23)=[CH:4][CH:3]=1.[CH3:29]COCC>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[C:17]3[C:16]([CH:18]([OH:20])[CH3:19])=[CH:15][C:14]([F:21])=[CH:13][C:12]=3[N:11]3[CH2:22][CH2:23][CH:24]([CH2:25][C:26]([O:28][CH3:29])=[O:27])[C:10]=23)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 3283Diethyl EtherHCID 10112823HCID 10112823, compound

Product 1

HCID 91424771HCID 91424771, compound

Procedure

(+/−)-[9-[(4-Chlorophenyl)sulfanyl]-6-fluoro-8-(1-hydroxyethyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetic acid (Example 14, 100 mg) was esterified in Et2O by addition of an excess of CH2N2. After removal of the solvents, the title ester was obtained quantitatively as a pale yellow solid and used as such.

Workup

  1. customAfter removal of the solvents

Sources & evidence

ORD record
ord-05ec9a2d67304222a3262b71bc673d26
Source dataset
uspto-grants-2006_12
Patent number
US07144913B2

Reaction notes

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