反应详情

To a solution of 2-bromo-4-fluorobenzaldehyde (50 g, 246 mmol), in MeOH (500 mL) in a 15° C. water bath was added a 25% solution of NaOMe/MeOH (88 mL). The mixture was stirred at r.t. for 1 hour followed by 2 hours at reflux. The solid was filtered and the filtrate was concentrated to dryness to give a second crop of solid. Both crops were taken up in CH2Cl2/H2O. After washing with H2O, the organic phase was dried (MgSO4), filtered, and evaporated to give an off-white solid (52.2 g).

1. waitfollowed by 2 hours
2. temperatureat reflux
3. filtrationThe solid was filtered
4. concentrationthe filtrate was concentrated to dryness
5. customto give a second crop of solid
6. washAfter washing with H2O
7. dry with materialthe organic phase was dried (MgSO4)
8. filtrationfiltered
9. customevaporated