Benzyl Bromide → HCID 131726143, compound

Participants

Reaction Steps

To a solution of the alcohol from Step 2 (0.19 g, 0.59 mmol) and benzyl bromide (0.10 mL, 0.88 mmol) in DMF (4 mL) at 0° C. was added Cs2CO3 (0.29 g, 0.88 mmol). The mixture was stirred at RT for 1 hour, and then saturated NH4Cl solution and H2O were added. The product was extracted with 1:1 EtOAc:Et2O and the organic layer was washed with H2O and brine. After drying (MgSO4), filtering, and removal of solvent, the crude product was purified by flash chromatography (1:2 EtOAc:hexane) to give a tan coloured foam (0.23 g).

Provenance & Evidence