Acetic Acid → HCID 10184165, compound

Participants

Reaction Steps

To a solution of the ester of Step 4 (140 mg) in THF/MeOH (3/1) mixture at r.t. was added 1 M LiOH (aqueous solution). The reaction mixture was stirred at r.t. for 2 hours and AcOH was added and the solvent was evaporated. The residue was taken up in EtOAc/H2O and the organic phase was washed with brine, dried (MgSO4), filtered and evaporated. The residue was purified by silica gel chromatography eluting with 1% AcOH in EtOAc to give 100 mg of the title compound.

Provenance & Evidence