Isopropyl iodide → HCID 91523227, compound

Participants

Reaction Steps

To methyl [6-hydroxy-8-(methylsulfonyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetate (Example 23, Step 2, 130 mg, 0.4 mmol) in DMF (1.5 mL) at r.t. was added 2-iodopropane (300 μL, 3 mmol) and Cs2CO3 (300 mg, 0.92 mmol). The reaction mixture was stirred for 15 minutes, and was then quenched with saturated aqueous NH4Cl and extracted with EtOAc. The combined organic layers were dried over NaSO4 and concentrated. The residue was purified by silica gel chromatography to give the title compound (100 mg).

Provenance & Evidence