Acetic Acid → HCID 10228407, compound

Participants

Reaction Steps

To a solution of the ester of Step 2 (70 mg) in THF/MeOH (3:1) mixture at r.t. was added 1 M LiOH aqueous solution (1 mL). The reaction mixture was stirred at r.t. for 1 hour. Then AcOH was added. The aqueous layer was extracted with EtOAC and the combined organic layers were dried over Na2SO4 and concentrated. The residue was purified by silica gel chromatography, eluting with 1% AcOH in EtOAc to give 60 mg of the title compound.

Provenance & Evidence