Benzyl Bromide → HCID 91009143, compound

Participants

Reaction Steps

To the compound of Step 3 (130 mg, 0.45 mmol) in DMF (2 mL) at 0° C., was added benzyl bromide (100 mL) and Cs2CO3 (300 mg, 0.92 mmol). The reaction mixture was warmed to r.t for 1 hour. The reaction was quenched with saturated aqueous NH4Cl and extracted with EtOAc. The combined organic layers were dried over Na2SO4 and concentrated. The residue was purified by silica gel chromatography to give the title compound (130 mg).

Provenance & Evidence