Potassium Carbonate → HCID 91586804, compound

Participants

Reaction Conditions

Reaction Steps

To the compound of Step 2 (53 mg, 0.089 mmol) in toluene/EtOH 3:1 mixture (4 mL) was added 4-chlorophenylboronic acid (28 mg, 0.18 mmol), K2CO3 (18 mg, 0.13 mmol), and tetrakis (triphenylphosphine) palladium (0) (5.1 mg, 0.04 mmol). The reaction mixture was stirred at 80° C. overnight. The reaction was quenched with saturated aqueous NH4Cl and extracted with EtOAc. The combined organic layers were dried over Na2SO4 and concentrated. The residue was purified by silica gel chromatography to provide the title compound (40 mg)

Provenance & Evidence