Acetic Acid → HCID 91336602, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (+/−)-methyl {8-bromo-9-[(4-chlorophenyl)thio]-6-cyano-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl}acetate (example 31, Step 1, 200 mg, 0.42 mmol) in toluene (3 mL) was added azidotributyltin (279 mg, 0.84 mmol). The reaction mixture was stirred at 90° C. for 16 hours, AcOH (1 mL) was added and the reaction was stirred for 2 hours and concentrated. The residue was swished in acetone/hexane 1:2 to give 160 mg of the title compound as a white solid used as such for next reaction.

Provenance & Evidence