Triphenylarsine → HCID 58760715, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (4S)-4-benzyl-3-({8-bromo-9-[(4-chlorophenyl)thio]-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl}acetyl)-1,3-oxazolidin-2-one (Example 7A, Step 3, 230 mg, 0.38 mmol) in DMF (4 mL) were added tris(dibenzylideneacetone)dipalladium(0) (37 mg, 0.04 mmol), triphenyl arsine (49 mg, 0.16 mmol) and 1-methyl-2-(tributylstannyl)-1H-pyrrole (211 mg, 0.57 mmol). The mixture was degassed and stirred at 90° C. for 4 hours. The reaction was poured in 1N HCl and extracted with EtOAc. The combined organic layers were washed with brine, dried over Na2SO4 and concentrated. The residue was purified by silica gel chromatography eluted with 20% EtOAc/toluene to give 240 mg of the title compound as an orange oil.

Provenance & Evidence