Trifluoroacetic acid → HCID 10222859, compound

Participants

Reaction Steps

To a solution of (+/−)-methyl [9-[(4-chlorophenyl)thio]-6-fluoro-8-(1-hydroxyethyl)-2,3-dihydro-1H-pytrolo[1,2-a]indol-1-yl]acetate (see Example 14, 85 mg) in CH2Cl2 were added trifluoroacetic acid (0.5 mL) and triethylsilane (0.2 mL). The mixture was stirred for 1 hour at r.t. and solvent was removed. The residue was purified by silica gel chromatography eluted with 30% EtOAc/hexane to give 70 mg of the title compound as a white foam which has hydrolyzed following the procedures described in Step 10 of Example 7.

Provenance & Evidence