1-Methyl-5-(tributylstannyl)-1H-pyrazole → (+/-)-[9-[(4-chlorophenyl)thio]-6-fluoro-8-(1-methyl-1H-pyrazol-5-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetic acid

Participants

Reaction Steps

Starting from (+/−)-methyl{8-bromo-9-[(4-chlorophenyl)thio]-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl}acetate (Example 7, Step 9, 200 mg, 0.43 mmol) and 1-methyl-5-(tributylstannyl)-1H-pyrazole (239 mg, 0.64 mmol), the title compound was synthesized following the procedures described in Example 42 and Step 10 of Example 7.

Provenance & Evidence