[(1r)-8-Bromo-6-fluoro-2,3-dihydro-1h-pyrrolo[1,2-a]indol-1-yl]acetic acid → HCID 86594293, compound

HRID 857383Notes

Reaction equation

HRID 857383 reaction equation
Br[C:2]1[C:3]2C=C3[C@@H](CC(O)=O)CCN3C=2C=C(F)[CH:10]=1.[CH3:19][O:20][C:21](=[O:37])[CH2:22][C@@H:23]1[C:27]2=[CH:28][C:29]3[C:30](Br)=[CH:31][C:32]([F:35])=[CH:33][C:34]=3[N:26]2[CH2:25][CH2:24]1>>[CH3:19][O:20][C:21](=[O:37])[CH2:22][C@@H:23]1[C:27]2=[CH:28][C:29]3[C:30]([CH:2]([CH3:3])[CH3:10])=[CH:31][C:32]([F:35])=[CH:33][C:34]=3[N:26]2[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 69562192[(1r)-8-Bromo-6-fluoro-2,3-dihydro-1h-pyrrolo[1,2-a]indol-1-yl]acetic acidHCID 86335761Methyl[(1r)-8-bromo-6-fluoro-2,3-dihydro-1h-pyrrolo[1,2-a]indol-1-yl]acetate

Product 1

HCID 86594293HCID 86594293, compound

Procedure

Starting from [(1R)-8-bromo-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetic acid (from Step 1 of Example 62A) which was converted to methyl[(1R)-8-bromo-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetate by addition of CH2N2, the title compound was synthesized following the procedures described in Steps 1 and 2 of Example 44.

Sources & evidence

ORD record
ord-c8e4f59004554248b39bfec8ca3333d9
Source dataset
uspto-grants-2006_12
Patent number
US07144913B2

Reaction notes

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