HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tributylphenyltin → (+/-)-{9-[(4-chlorophenyl)thio]-6-fluoro-8-phenyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl}acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tributylphenyltin | HCID 607632 | — |
| Reactant | (+)-methyl{8-bromo-9-[(4-chlorophenyl)thio]-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl}acetate | HCID 21867555 | — |
| Product | (+/-)-{9-[(4-chlorophenyl)thio]-6-fluoro-8-phenyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl}acetic acid | HCID 10275781 | — |
Reaction Steps
Starting from (+/−)-methyl{8-bromo-9-[(4-chlorophenyl)thio]-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl}acetate (200 mg, 0.43 mmol) and tributyl(phenyl)stannane the title compound was synthesized following the procedures described in Example 42 and Step 10 of Example 7.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07144913B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-8dfba1dfacd14e69aa6e7cddddc95563 |
| Source note | uspto-grants-2006_12 |