2-(Tri-n-butylstannyl)thiophene → (+/-)-{9-[(4-chlorophenyl)thio]-6-fluoro-8-thien-2-yl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl}acetic acid

Participants

Role	Name	HCID	Charge
Reactant	2-(Tri-n-butylstannyl)thiophene	HCID 2779373	—
Reactant	(+)-methyl{8-bromo-9-[(4-chlorophenyl)thio]-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl}acetate	HCID 21867555	—
Product	(+/-)-{9-[(4-chlorophenyl)thio]-6-fluoro-8-thien-2-yl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl}acetic acid	HCID 10298095	—

Reaction Steps

Starting from (+/−)-methyl{8-bromo-9-[(4-chlorophenyl)thio]-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl}acetate and tributyl(thien-2-yl)-stannane, the title compound was synthesized following the procedures described in Example 42 and Step 10 of Example 7.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07144913B2
Source dataset	uspto-grants-2006_12
ORD ID	ord-25c0f796a6a4455cb8a9f99f9b1546e0
Source note	uspto-grants-2006_12