1-methyl-2-(tributylstannyl)-1H-pyrrole → HCID 58760764, compound

HRID 857389Notes

Reaction equation

HRID 857389 reaction equation
C[CH:2]([CH:6]1[C:10]2=[C:11]([S:25][C:26]3[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=3)[C:12]3[C:13](Br)=[CH:14][C:15]([C:18]4[N:19]=[N:20][N:21]([CH3:23])[N:22]=4)=[CH:16][C:17]=3[N:9]2[CH2:8][CH2:7]1)[C:3]([O-:5])=[O:4].[CH3:33][N:34]1[CH:38]=[CH:37][CH:36]=[C:35]1[Sn](CCCC)(CCCC)CCCC>>[Cl:32][C:29]1[CH:30]=[CH:31][C:26]([S:25][C:11]2[C:12]3[C:13]([C:35]4[N:34]([CH3:33])[CH:38]=[CH:37][CH:36]=4)=[CH:14][C:15]([C:18]4[N:19]=[N:20][N:21]([CH3:23])[N:22]=4)=[CH:16][C:17]=3[N:9]3[CH2:8][CH2:7][CH:6]([CH2:2][C:3]([OH:5])=[O:4])[C:10]=23)=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 27693971-methyl-2-(tributylstannyl)-1H-pyrroleHCID 86760310HCID 86760310, compound

Product 1

HCID 58760764HCID 58760764, compound

Procedure

Starting from (+/−)-methyl[8-bromo-9-[(4-chlorophenyl)thio]-6-(2-methyl-2H-tetrazol-5-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetate (see Example 32) and 1-methyl-2-(tributylstannyl)-1H-pyrrole, the title compound was synthesized following the procedures described in Example 42 and Step 10 of Example 7.

Sources & evidence

ORD record
ord-a9dbc0786eef4ee2a872de28acb61a01
Source dataset
uspto-grants-2006_12
Patent number
US07144913B2

Reaction notes

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