1-methyl-2-(tributylstannyl)-1H-pyrrole → HCID 10138836, compound

HRID 857391Notes

Reaction equation

HRID 857391 reaction equation
C[CH:2]([CH:6]1[C:10]2=[C:11]([C:20](=[O:28])[C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=3)[C:12]3[C:13](Br)=[CH:14][C:15]([F:18])=[CH:16][C:17]=3[N:9]2[CH2:8][CH2:7]1)[C:3]([O-:5])=[O:4].[CH3:29][N:30]1[CH:34]=[CH:33][CH:32]=[C:31]1[Sn](CCCC)(CCCC)CCCC>>[Cl:27][C:24]1[CH:23]=[CH:22][C:21]([C:20]([C:11]2[C:12]3[C:13]([C:31]4[N:30]([CH3:29])[CH:34]=[CH:33][CH:32]=4)=[CH:14][C:15]([F:18])=[CH:16][C:17]=3[N:9]3[CH2:8][CH2:7][CH:6]([CH2:2][C:3]([OH:5])=[O:4])[C:10]=23)=[O:28])=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 27693971-methyl-2-(tributylstannyl)-1H-pyrroleHCID 86760312HCID 86760312, compound

Product 1

HCID 10138836HCID 10138836, compound

Procedure

Starting from (+/−)-methyl[8-bromo-9-(4-chlorobenzoyl)-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetate (see Example 69) and 1-methyl-2-(tributylstannyl)-1H-pyrrole, the title compound was synthesized following the procedures described in Example 42 and Step 10 of Example 7.

Sources & evidence

ORD record
ord-805c8cd825f9423692808a8e1834742a
Source dataset
uspto-grants-2006_12
Patent number
US07144913B2

Reaction notes

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