2,4-Dichlorobenzaldehyde → HCID 69561523, compound

HRID 857392Notes

Reaction equation

HRID 857392 reaction equation
C[O:2][C:3](=[O:22])[CH2:4][C@@H:5]1[C:9]2=[CH:10][C:11]3[C:12]([S:18]([CH3:21])(=[O:20])=[O:19])=[CH:13][C:14]([F:17])=[CH:15][C:16]=3[N:8]2[CH2:7][CH2:6]1.[Cl:23][C:24]1[CH:31]=[C:30]([Cl:32])[CH:29]=[CH:28][C:25]=1[CH:26]=O>>[Cl:23][C:24]1[CH:31]=[C:30]([Cl:32])[CH:29]=[CH:28][C:25]=1[CH2:26][C:10]1[C:11]2[C:12]([S:18]([CH3:21])(=[O:20])=[O:19])=[CH:13][C:14]([F:17])=[CH:15][C:16]=2[N:8]2[CH2:7][CH2:6][C@H:5]([CH2:4][C:3]([OH:2])=[O:22])[C:9]=12

Participants

3

Reactant 2

HCID 134042,4-DichlorobenzaldehydeHCID 90997030HCID 90997030, compound

Product 1

HCID 69561523HCID 69561523, compound

Procedure

Starting from methyl[(1R)-6-fluoro-8-(methylsulfonyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetate (Example 62A, Step 2, 120 mg, 0.37 mmol) and 2,4-dichlorobenzaldehyde (71 mg, 0.51 mmol), the title compound was synthesized following the procedures as described in Step 1 of Example 60 and Step 10 of Example 7.

Sources & evidence

ORD record
ord-7680fb2d75d649219cf2cb8443d131fa
Source dataset
uspto-grants-2006_12
Patent number
US07144913B2

Reaction notes

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