Stannane → HCID 58760710, compound

HRID 857393Notes

Reaction equation

HRID 857393 reaction equation
C[CH:2]([CH:6]1[C:10]2=[C:11]([C:20](=[O:28])[C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=3)[C:12]3[C:13](Br)=[CH:14][C:15]([F:18])=[CH:16][C:17]=3[N:9]2[CH2:8][CH2:7]1)[C:3]([O-:5])=[O:4].[SnH4]>>[Cl:27][C:24]1[CH:25]=[CH:26][C:21]([C:20]([C:11]2[C:12]3[C:13]([C:12]4[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=4)=[CH:14][C:15]([F:18])=[CH:16][C:17]=3[N:9]3[CH2:8][CH2:7][CH:6]([CH2:2][C:3]([OH:5])=[O:4])[C:10]=23)=[O:28])=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 123161StannaneHCID 86760312HCID 86760312, compound

Product 1

HCID 58760710HCID 58760710, compound

Procedure

Starting from (+/−)-methyl[8-bromo-9-(4-chlorobenzoyl)-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetate (Example 61, Step 1, 100 mg, 0.22 mmol) and tributylephenyl)stannane (121 mg, 0.33 mmol), the title compound was synthesized following the procedures as described in Example 42 and Step 10 of Example 7.

Sources & evidence

ORD record
ord-1473a64ca7cf42d8a9f0ac834867cc18
Source dataset
uspto-grants-2006_12
Patent number
US07144913B2

Reaction notes

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