2-(Tri-n-butylstannyl)thiophene → HCID 58760768, compound

HRID 857394Notes

Reaction equation

HRID 857394 reaction equation
C[CH:2]([CH:6]1[C:10]2=[C:11]([C:20](=[O:28])[C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=3)[C:12]3[C:13](Br)=[CH:14][C:15]([F:18])=[CH:16][C:17]=3[N:9]2[CH2:8][CH2:7]1)[C:3]([O-:5])=[O:4].C([Sn](CCCC)(CCCC)[C:34]1[S:35][CH:36]=[CH:37][CH:38]=1)CCC>>[Cl:27][C:24]1[CH:23]=[CH:22][C:21]([C:20]([C:11]2[C:12]3[C:13]([C:34]4[S:35][CH:36]=[CH:37][CH:38]=4)=[CH:14][C:15]([F:18])=[CH:16][C:17]=3[N:9]3[CH2:8][CH2:7][CH:6]([CH2:2][C:3]([OH:5])=[O:4])[C:10]=23)=[O:28])=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 27793732-(Tri-n-butylstannyl)thiopheneHCID 86760312HCID 86760312, compound

Product 1

HCID 58760768HCID 58760768, compound

Procedure

Starting from (+/−)-methyl[8-bromo-9-(4-chlorobenzoyl)-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetate and tributyl(thien-2-yl)stannane, the title compound was synthesized following the procedures described in Example 42 and Step 10 of Example 7.

Sources & evidence

ORD record
ord-8f84c0cd4a764e81862c9a4c8d35d250
Source dataset
uspto-grants-2006_12
Patent number
US07144913B2

Reaction notes

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