Hydrochloric Acid → HCID 58760759, compound

Participants

Reaction Conditions

Reaction Steps

To the compound of Step 7 (40 mg) in 2-butanone (4 mL) was added 6N HCl (0.5 mL). The mixture was stirred at 80° C. for 3 hours, cooled to r.t., diluted with H2O and the aqueous layer was extracted with EtOAc. The combined organic layers were dried over Na2SO4 and concentrated. The residue was purified by silica gel chromatography eluted with 40% EtOAc/hexane containing 1% AcOH to give 23 mg of the title compound as a white solid.

Provenance & Evidence