反应详情

5.60 g (17.6 mmol) of tert-butyl 7-benzyl-9-oxa-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate are dissolved in 100 ml of ethanol, 1.00 g of 10% palladium on activated carbon is added, and hydrogenation is carried out at 100° C. and 100 bar. The catalyst is filtered off with suction, and the filtrate is concentrated, whereupon 3.80 g (94.5% of theory) of pure product crystallize out.

1. customis carried out at 100° C.
2. filtrationThe catalyst is filtered off with suction
3. concentrationthe filtrate is concentrated, whereupon 3.80 g (94.5% of theory) of pure product
4. customcrystallize out