HCID 21867442, compound → (+/-)-[8-BROMO-9-(4-CHLORO-2-IODOBENZOYL)-6-FLUORO-2,3-DIHYDRO-1H-PYRROLO[1,2-a]INDOL-1-YL]ACETIC ACID

HRID 857400Notes

Reaction equation

HRID 857400 reaction equation
C[CH:2]([CH:6]1[C:10]2=[CH:11][C:12]3[C:13]([Br:19])=[CH:14][C:15]([F:18])=[CH:16][C:17]=3[N:9]2[CH2:8][CH2:7]1)[C:3]([O-:5])=[O:4].[Cl:20][C:21]1[CH:29]=[CH:28][C:24]([C:25](Cl)=[O:26])=[C:23]([I:30])[CH:22]=1>>[Br:19][C:13]1[C:12]2[C:11]([C:25](=[O:26])[C:24]3[CH:28]=[CH:29][C:21]([Cl:20])=[CH:22][C:23]=3[I:30])=[C:10]3[CH:6]([CH2:2][C:3]([OH:5])=[O:4])[CH2:7][CH2:8][N:9]3[C:17]=2[CH:16]=[C:15]([F:18])[CH:14]=1

Participants

3

Reactant 2

HCID 21867442HCID 21867442, compoundHCID 218675214-Chloro-2-iodobenzoyl chloride

Product 1

HCID 10166983(+/-)-[8-BROMO-9-(4-CHLORO-2-IODOBENZOYL)-6-FLUORO-2,3-DIHYDRO-1H-PYRROLO[1,2-a]INDOL-1-YL]ACETIC ACID

Procedure

Starting from (+/−)-methyl(8-bromo-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate (example 7, Step 8) and 4-chloro-2-iodobenzoyl chloride, the title compound was synthesized following the procedures described in Step 1 of Example 61 and Step 10 of Example 7.

Sources & evidence

ORD record
ord-c72de2f27226480a89b927f9f38527a1
Source dataset
uspto-grants-2006_12
Patent number
US07144913B2

Reaction notes

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