Acetic Acid → HCID 10300251, compound

Participants

Reaction Steps

To a solution of the compound of Step 1 (30 mg) in a 3/1 mixture of THF/MeOH (3 mL) was added 1N LiOH (1 mL, aqueous solution). The reaction mixture was stirred at r.t. for 16 h and AcOH (0.5 mL) and brine (5 mL) were added. The aqueous layer was extracted with EtOAc. The combined organic layers were dried over Na2SO4 and concentrated. The residue was swished in EtOAc to give 18 mg of the title compound as a white solid.

Provenance & Evidence