4-Chloro-2-iodobenzoyl chloride → HCID 69561752, compound

HRID 857402Notes

Reaction equation

HRID 857402 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[C:4]([I:11])[CH:3]=1.C[O:13][C:14](=[O:32])[CH2:15][C@@H:16]1[C:20]2=[CH:21][C:22]3[C:23]([CH:29]([CH3:31])[CH3:30])=[CH:24][C:25]([F:28])=[CH:26][C:27]=3[N:19]2[CH2:18][CH2:17]1>>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([C:21]2[C:22]3[C:23]([CH:29]([CH3:30])[CH3:31])=[CH:24][C:25]([F:28])=[CH:26][C:27]=3[N:19]3[CH2:18][CH2:17][C@H:16]([CH2:15][C:14]([OH:32])=[O:13])[C:20]=23)=[O:7])=[C:4]([I:11])[CH:3]=1

Participants

3

Reactant 2

HCID 218675214-Chloro-2-iodobenzoyl chlorideHCID 86594293HCID 86594293, compound

Product 1

HCID 69561752HCID 69561752, compound

Procedure

Starting from 4-chloro-2-iodobenzoyl chloride (542 mg, 1.8 mmol) and methyl[(1R)-6-fluoro-8-isopropyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetate (Example 44A, Step 1, 173 mg, 0.6 mmol), the title compound was synthesized following the procedures described in Step 1 of Example 61 and Step 10 of Example 7.

Sources & evidence

ORD record
ord-5c1f354b33854899b8b2c11389104563
Source dataset
uspto-grants-2006_12
Patent number
US07144913B2

Reaction notes

Loading…