Ammonium Chloride → HCID 91342956, compound

Participants

Reaction Steps

To a suspension of methyltriphenylphosphonium bromide (536 mg, 1.5 mmol) in THF (7 mL) at r.t. was added potassium tert-butoxide (1.5 mL, 1M THF solution). The mixture was stirred for 30 minutes at r.t. and a solution of the compound of Step 1 (190 mg, 0.38 mmol) in THF (7 mL) was added. The reaction mixture was stirred at 60° C. for 2 h, cooled and poured into aqueous saturated NH4Cl. The phases were separated and the aqueous layer was extracted with EtOAc. The combined organic layers were dried over Na2SO4 and concentrated. The residue was purified by silica gel chromatography eluted with 20% EtOAc/hexane to give 150 mg of the title compound.

Provenance & Evidence