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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 857410Generated: October 30, 2026

8-Quinolineboronic acid → (+/-)-{9-[(4-CHLOROPHENYL)THIO]-6-FLUORO-8-QUINOLIN-8-YL-2,3-DIHYDRO-1H-PYRROLO[1,2-a]INDOL-1-YL}ACETIC ACID

https://huagongshe.com/reaction/857410

Reaction equation

Participants

RoleNameHCIDCharge
Reactant8-Quinolineboronic acidHCID 2734380—
Reactant(+)-methyl{8-bromo-9-[(4-chlorophenyl)thio]-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl}acetateHCID 21867555—
Product(+/-)-{9-[(4-CHLOROPHENYL)THIO]-6-FLUORO-8-QUINOLIN-8-YL-2,3-DIHYDRO-1H-PYRROLO[1,2-a]INDOL-1-YL}ACETIC ACIDHCID 10300757—

Reaction Steps

Starting from (+/−)-methyl[8-bromo-9-[(4-chlorophenyl)sulfanyl]-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetate (Example 7, Step 9) and quinolin-8-ylboronic acid, the title compound was synthesized following the procedures described in Example 108.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07144913B2
Source datasetuspto-grants-2006_12
ORD IDord-eb73b743f42342eba14285f1e846956b
Source noteuspto-grants-2006_12