(1-Benzothiophen-3-yl)boronic acid → HCID 10279059, compound

HRID 857411Notes

Reaction equation

HRID 857411 reaction equation
C[CH:2]([CH:6]1[C:10]2=[C:11]([S:20][C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=3)[C:12]3[C:13](Br)=[CH:14][C:15]([F:18])=[CH:16][C:17]=3[N:9]2[CH2:8][CH2:7]1)[C:3]([O-:5])=[O:4].[S:28]1[C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=2[C:30](B(O)O)=[CH:29]1>>[S:28]1[C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=2[C:30]([C:13]2[C:12]3[C:11]([S:20][C:21]4[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=4)=[C:10]4[CH:6]([CH2:2][C:3]([OH:5])=[O:4])[CH2:7][CH2:8][N:9]4[C:17]=3[CH:16]=[C:15]([F:18])[CH:14]=2)=[CH:29]1

Participants

3

Reactant 2

HCID 2776344(1-Benzothiophen-3-yl)boronic acidHCID 21867555(+)-methyl{8-bromo-9-[(4-chlorophenyl)thio]-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl}acetate

Product 1

HCID 10279059HCID 10279059, compound

Procedure

Starting from (+/−)-methyl[8-bromo-9-[(4-chlorophenyl)sulfanyl]-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetate (Example 7, Step 9) and 1-benzothien-3-ylboronic acid, the title compound was synthesized following the procedures described in Example 108.

Sources & evidence

ORD record
ord-c00bdf66d4c5400ba24b21f1a079a9d1
Source dataset
uspto-grants-2006_12
Patent number
US07144913B2

Reaction notes

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