3,5-Dimethylisoxazole-4-boronic acid → HCID 58760765, compound

HRID 857412Notes

Reaction equation

HRID 857412 reaction equation
Br[C:2]1[C:3]2[C:4]([S:20][C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=3)=[C:5]3[CH:14]([CH2:15][C:16]([O:18]C)=[O:17])[CH2:13][CH2:12][N:6]3[C:7]=2[CH:8]=[C:9]([F:11])[CH:10]=1.[CH3:28][C:29]1[C:33](B(O)O)=[C:32]([CH3:37])[O:31][N:30]=1>>[Cl:27][C:24]1[CH:23]=[CH:22][C:21]([S:20][C:4]2[C:3]3[C:2]([C:33]4[C:29]([CH3:28])=[N:30][O:31][C:32]=4[CH3:37])=[CH:10][C:9]([F:11])=[CH:8][C:7]=3[N:6]3[CH2:12][CH2:13][CH:14]([CH2:15][C:16]([OH:18])=[O:17])[C:5]=23)=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 27343463,5-Dimethylisoxazole-4-boronic acidHCID 86594288HCID 86594288, compound

Product 1

HCID 58760765HCID 58760765, compound

Procedure

Starting from (+/−)-methyl[8-bromo-9-[(4-chlorophenyl)sulfanyl]-6-fluoro-2,3-dihydro-1H-pyrrolo[1.12-a]indol-1-yl]acetate (Example 7, Step 9) and 3,5-dimethylisoxazol-4-ylboronic acid, the title compound was synthesized following the procedures described Example 108.

Sources & evidence

ORD record
ord-a5db2b6bb18a478d89b54a0e517c22d4
Source dataset
uspto-grants-2006_12
Patent number
US07144913B2

Reaction notes

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