4,4,5,5-Tetramethyl-2-(4-methylthiophen-3-yl)-1,3,2-dioxaborolane → HCID 10116202, compound

HRID 857413Notes

Reaction equation

HRID 857413 reaction equation
C[CH:2]([CH:6]1[C:10]2=[C:11]([S:20][C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=3)[C:12]3[C:13](Br)=[CH:14][C:15]([F:18])=[CH:16][C:17]=3[N:9]2[CH2:8][CH2:7]1)[C:3]([O-:5])=[O:4].CC1(C)C(C)(C)OB([C:36]2[C:40]([CH3:41])=[CH:39][S:38][CH:37]=2)O1>>[Cl:27][C:24]1[CH:23]=[CH:22][C:21]([S:20][C:11]2[C:12]3[C:13]([C:36]4[C:40]([CH3:41])=[CH:39][S:38][CH:37]=4)=[CH:14][C:15]([F:18])=[CH:16][C:17]=3[N:9]3[CH2:8][CH2:7][CH:6]([CH2:2][C:3]([OH:5])=[O:4])[C:10]=23)=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 162183474,4,5,5-Tetramethyl-2-(4-methylthiophen-3-yl)-1,3,2-dioxaborolaneHCID 21867555(+)-methyl{8-bromo-9-[(4-chlorophenyl)thio]-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl}acetate

Product 1

HCID 10116202HCID 10116202, compound

Procedure

Starting from (+/−)-methyl[8-bromo-9-[(4-chlorophenyl)sulfanyl]-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetate (Example 7, Step 9) and 4,4,5,5-tetramethyl-2-(4-methylthien-3-yl)-1,3,2-dioxaborolane, the title compound was synthesized following the procedures described Example 108.

Sources & evidence

ORD record
ord-69d6041d6eb246c3ab2a7d2e176557aa
Source dataset
uspto-grants-2006_12
Patent number
US07144913B2

Reaction notes

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