(3-(1H-pyrazol-1-yl)phenyl)boronic acid → (+/-)-{9-[(4-CHLOROPHENYL)THIO]-6-FLUORO-8-[3-(1H-PYRAZOL-1-YL)PHENYL]-2,3-DIHYDRO-1H-PYRROLO[1,2-a]INDOL-1-YL}ACETIC ACID

Participants

Role	Name	HCID	Charge
Reactant	(3-(1H-pyrazol-1-yl)phenyl)boronic acid	HCID 16640530	—
Reactant	(+)-methyl{8-bromo-9-[(4-chlorophenyl)thio]-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl}acetate	HCID 21867555	—
Product	(+/-)-{9-[(4-CHLOROPHENYL)THIO]-6-FLUORO-8-[3-(1H-PYRAZOL-1-YL)PHENYL]-2,3-DIHYDRO-1H-PYRROLO[1,2-a]INDOL-1-YL}ACETIC ACID	HCID 58760773	—

Reaction Steps

Starting from (+/−)-methyl[8-bromo-9-[(4-chlorophenyl)sulfanyl]-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetate (Example 7, Step 9) and 3-(1H-pyrazol-1-yl)phenylboronic acid, the title compound was synthesized following the procedures described Example 108.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07144913B2
Source dataset	uspto-grants-2006_12
ORD ID	ord-f7ee471095614e03b7fa6dbc3aac220d
Source note	uspto-grants-2006_12