3,4-Dichlorobenzeneboronic acid → HCID 10186356, compound

HRID 857416Notes

Reaction equation

HRID 857416 reaction equation
C[CH:2]([CH:6]1[C:10]2=[C:11]([S:20][C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=3)[C:12]3[C:13](Br)=[CH:14][C:15]([F:18])=[CH:16][C:17]=3[N:9]2[CH2:8][CH2:7]1)[C:3]([O-:5])=[O:4].[Cl:28][C:29]1[CH:30]=[C:31](B(O)O)[CH:32]=[CH:33][C:34]=1[Cl:35]>>[Cl:27][C:24]1[CH:23]=[CH:22][C:21]([S:20][C:11]2[C:12]3[C:13]([C:32]4[CH:31]=[CH:30][C:29]([Cl:28])=[C:34]([Cl:35])[CH:33]=4)=[CH:14][C:15]([F:18])=[CH:16][C:17]=3[N:9]3[CH2:8][CH2:7][CH:6]([CH2:2][C:3]([OH:5])=[O:4])[C:10]=23)=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 27343303,4-Dichlorobenzeneboronic acidHCID 21867555(+)-methyl{8-bromo-9-[(4-chlorophenyl)thio]-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl}acetate

Product 1

HCID 10186356HCID 10186356, compound

Procedure

Starting from (+/−)-methyl[8-bromo-9-[(4-chlorophenyl)sulfanyl]-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetate (Example 7, Step 9) and 3,4-dichlorophenylboronic acid, the title compound was synthesized following the procedures described in Example 108.

Sources & evidence

ORD record
ord-f50012d1e2df494da79859a4c4eae720
Source dataset
uspto-grants-2006_12
Patent number
US07144913B2

Reaction notes

Loading…