HuagongsheHuagongshe Chemistry Print Report · For research reference only
Quinolin-6-ylboronic Acid (contains varying amounts of Anhydride) → (+/-)-{9-[(4-chlorophenyl)thio]-6-fluoro-8-quinolin-6-yl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl}acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Quinolin-6-ylboronic Acid (contains varying amounts of Anhydride) | HCID 4192671 | — |
| Reactant | (+)-methyl{8-bromo-9-[(4-chlorophenyl)thio]-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl}acetate | HCID 21867555 | — |
| Product | (+/-)-{9-[(4-chlorophenyl)thio]-6-fluoro-8-quinolin-6-yl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl}acetic acid | HCID 58760746 | — |
Reaction Steps
Starting from (+/−)-methyl[8-bromo-9-[(4-chlorophenyl)sulfanyl]-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetate (Example 7, Step 9) and quinolin-6-ylboronic acid, the title compound was synthesized following the procedures described in Example 108.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07144913B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-63780ffdd7294110b49622f1bacd8973 |
| Source note | uspto-grants-2006_12 |