1-Naphthalenecarbonyl chloride → HCID 58760748, compound

HRID 857419Notes

Reaction equation

HRID 857419 reaction equation
C[CH:2]([CH:6]1[C:10]2=[CH:11][C:12]3[C:13]([CH:19]([CH3:21])[CH3:20])=[CH:14][C:15]([F:18])=[CH:16][C:17]=3[N:9]2[CH2:8][CH2:7]1)[C:3]([O-:5])=[O:4].[C:22]1([C:32](Cl)=[O:33])[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH:25]=[CH:24][CH:23]=1>>[F:18][C:15]1[CH:14]=[C:13]([CH:19]([CH3:21])[CH3:20])[C:12]2[C:11]([C:32]([C:22]3[C:31]4[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=4)[CH:25]=[CH:24][CH:23]=3)=[O:33])=[C:10]3[CH:6]([CH2:2][C:3]([OH:5])=[O:4])[CH2:7][CH2:8][N:9]3[C:17]=2[CH:16]=1

Participants

3

Reactant 2

HCID 701461-Naphthalenecarbonyl chlorideHCID 21867413HCID 21867413, compound

Product 1

HCID 58760748HCID 58760748, compound

Procedure

Starting from methyl(6-fluoro-8-isopropyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate (Example 44, Step 2) and 1-naphthoyl chloride, the title compound was synthesized following the procedures described in Step 1 of Example 61 and Step 10 of Example 7.

Sources & evidence

ORD record
ord-618535c5bc544d8ba58bd67b6b149661
Source dataset
uspto-grants-2006_12
Patent number
US07144913B2

Reaction notes

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