2-Naphthoyl chloride → HCID 58760723, compound

HRID 857423Notes

Reaction equation

HRID 857423 reaction equation
C[CH:2]([CH:6]1[C:11]2=[CH:12][C:13]3[C:18]([N:10]2[CH2:9][CH2:8][CH2:7]1)=[CH:17][C:16]([F:19])=[CH:15][C:14]=3[CH:20]([CH3:22])[CH3:21])[C:3]([O-:5])=[O:4].[CH:23]1[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH:26]=[CH:25][C:24]=1[C:33](Cl)=[O:34]>>[F:19][C:16]1[CH:17]=[C:18]2[C:13]([C:12]([C:33]([C:24]3[CH:25]=[CH:26][C:27]4[C:32](=[CH:31][CH:30]=[CH:29][CH:28]=4)[CH:23]=3)=[O:34])=[C:11]3[CH:6]([CH2:2][C:3]([OH:5])=[O:4])[CH2:7][CH2:8][CH2:9][N:10]32)=[C:14]([CH:20]([CH3:21])[CH3:22])[CH:15]=1

Participants

3

Reactant 2

HCID 752462-Naphthoyl chlorideHCID 86760316HCID 86760316, compound

Product 1

HCID 58760723HCID 58760723, compound

Procedure

Starting from (+/−)-methyl(3-fluoro-1-isopropyl-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetate (Example 122, Step 4) and 2-naphthoyl chloride, the title compound was synthesized following the procedures described in Step 1 of Example 61 and Step 10 of Example 7.

Sources & evidence

ORD record
ord-17db7b2896734bf8a83142069a6a306b
Source dataset
uspto-grants-2006_12
Patent number
US07144913B2

Reaction notes

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