4-Chlorobenzoyl chloride → HCID 58760730, compound

HRID 857424Notes

Reaction equation

HRID 857424 reaction equation
C[CH:2]([CH:6]1[C:11]2=[CH:12][C:13]3[C:18]([N:10]2[CH2:9][CH2:8][CH2:7]1)=[CH:17][C:16]([F:19])=[CH:15][C:14]=3[CH:20]([CH3:22])[CH3:21])[C:3]([O-:5])=[O:4].[Cl:23][C:24]1[CH:32]=[CH:31][C:27]([C:28](Cl)=[O:29])=[CH:26][CH:25]=1>>[Cl:23][C:24]1[CH:32]=[CH:31][C:27]([C:28]([C:12]2[C:13]3[C:18](=[CH:17][C:16]([F:19])=[CH:15][C:14]=3[CH:20]([CH3:22])[CH3:21])[N:10]3[CH2:9][CH2:8][CH2:7][CH:6]([CH2:2][C:3]([OH:5])=[O:4])[C:11]=23)=[O:29])=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 85014-Chlorobenzoyl chlorideHCID 86760316HCID 86760316, compound

Product 1

HCID 58760730HCID 58760730, compound

Procedure

Starting from (+/−)-methyl(3-fluoro-1-isopropyl-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetate (Example 122, Step 4) and 4-chlorobenzoyl chloride, the title compound was synthesized following the procedures described in Step 1 of Example 61 and Step 10 of Example 7.

Sources & evidence

ORD record
ord-8ad7971ff9b947b3a8ac59536a1f11a2
Source dataset
uspto-grants-2006_12
Patent number
US07144913B2

Reaction notes

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