(Naphthalen-2-yl)boronic acid → HCID 58760718, compound

HRID 857425Notes

Reaction equation

HRID 857425 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1B(O)O.C[CH:15]([CH:19]1[C:23]2=[C:24](Br)[C:25]3[C:26]([S:32]([CH3:35])(=[O:34])=[O:33])=[CH:27][C:28]([F:31])=[CH:29][C:30]=3[N:22]2[CH2:21][CH2:20]1)[C:16]([O-:18])=[O:17]>>[F:31][C:28]1[CH:27]=[C:26]([S:32]([CH3:35])(=[O:34])=[O:33])[C:25]2[C:24]([C:2]3[CH:3]=[CH:4][C:5]4[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=4)[CH:1]=3)=[C:23]3[CH:19]([CH2:15][C:16]([OH:18])=[O:17])[CH2:20][CH2:21][N:22]3[C:30]=2[CH:29]=1

Participants

3

Reactant 2

HCID 2734375(Naphthalen-2-yl)boronic acidHCID 131726153HCID 131726153, compound

Product 1

HCID 58760718HCID 58760718, compound

Procedure

Starting from 2-naphthylboronic acid and (+/−)-methyl[9-bromo-6-fluoro-8-(methylsulfonyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetate (Example 126, Step 1), the title compound was synthesized following the procedures described in Step 2 of Example 126 and Step 10 of Example 7.

Sources & evidence

ORD record
ord-107b0275a56c4fc19bb32b1ae672f779
Source dataset
uspto-grants-2006_12
Patent number
US07144913B2

Reaction notes

Loading…